Medical University of South Carolina Showcase

Patient cohort identified from 2012-2015 NSQIP PUF.

Description of methods used to compile a comprehensive list of online educational dermatopathology resources.

Supplemental images for JAAD Dermatology Images - Pityriasis Rubra Pilaris

This data set includes full blots for main figures.

The primary purposes of this study were to: 1) extend prior investigations of post-stroke mediolateral foot placement accuracy during overground walking to include both stationary and more challenging shifting visual targets; and 2) relate mediolateral paretic foot placement accuracy to paretic hip abduction accuracy. We hypothesized that foot placement accuracy would be reduced for paretic steps in comparison to controls, and that paretic foot placement errors would be correlated with paretic hip abduction errors. This file contains data from both neurologically-intact control participants and people with chronic stroke (PwCS). Specifically, we provide data quantifying mediolateral foot placement error, step width, and walking speed while participants walked on a instrumented mat. In some trials, visual targets prescribing constant step widths were provided, while in other trials the visual targets shifted during the walking trial. We also provide data quantifying the accuracy of the PwCS participants performing an isolated hip abduction task.

Original, uncropped western blot image files.

Predictive pharmacokinetic data for every MEK-1 inhibitor approved by the FDA or in clinical trials.

Western blot and microscopy images of the article, A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer.

The fully synthetic neuroimaging dataset generated for analysis of fully synthetic data in the current study are available as Research Data from Mendeley Data. Ten fully synthetic datasets are included, with synthetic gray matter images (nifti files) that were generated based on simulated participant data (text files). The file Synthetic_predictors.tar.gz contains ten fully synthetic predictor tables with information for 264 simulated subjects. Due to large file sizes, a separate archive was created for each set of synthetic gray matter image data: RBS001.tar.gz, …, RBS010.tar.gz. Regression analyses were performed for each synthetic dataset, then average statistic maps were made for each contrast, which were then smoothed (see accompanying paper for additional information). The supplementary materials also include commented MATLAB and R code to implement the current neuroimaging data synthesis methods (SKexample.zip). The example data were selected from an earlier fMRI study (Kuchinsky et al., 2012) to demonstrate that the current approach can be used with other types of neuroimaging data. The example code can also be adapted to produce fully synthetic group-level datasets based on observed neuroimaging data from other sources. The zip archive includes a document with important information for performing the example analyses, and details that should be communicated with recipients of a synthetic neuroimaging dataset. Kuchinsky, S.E., Vaden, K.I., Keren, N.I., Harris, K.C., Ahlstrom, J.B., Dubno, J.R., Eckert, M.A., 2012. Word intelligibility and age predict visual cortex activity during word listening. Cerebral Cortex 22, 1360–71. https://doi.org/10.1093/cercor/bhr211

Mechanisms by which aging Alzheimer’s disease (AD) patients exhibit decreased cancer incidence are mainly unknown. Here, we demonstrate that mitochondrial localization of AD-associated amyloid precursor protein (APP) and its cleaved amyloid-β 40 (Aβ40), but not the mutant APP that lacks mitochondrial localization signal, inhibits lipid stress-mediated hyperactive mitophagy in aging T-cells, improving their anti-tumor functions. B16-derived melanoma or carcinogen-induced oral cancer growth is highly reduced in 3xTg AD mice, which is attenuated by T-cell depletion. Adoptive cell transfer (ACT)-based immunotherapy using aging T-cells isolated from 3xTg-AD/Pmel mice controlled B16-melanoma tumor growth in recipient mice compared to controls. The metabolic signature of aging stress-dependent mitophagy in mouse and human T-cells showed depletion of fumarate, and exogenous fumarate supplementation or whole mitochondria transfer phenocopied aging AD T-cells with improved anti-tumor functions in aging WT T-cells. Thus, this study explains how AD is linked to improved anti-tumor immunity which limits aging-stress-dependent tumor growth.